Providing healthy and balanced soundscapes is one of the most important challenges facing cities in the 21st century. Currently, the studies related to this issue assume a comprehensive approach, which carefully explores the interaction between citizens and their closest acoustic environment. This work examines the soundscape of the historic centers of Venice (Italy) and Popayán (Colombia). In this sense, cartographies of the physical factor and perceptual factor of the urban soundscape were carried out, in order to guarantee their effective evaluation. The results show diverse patterns of spatio-temporal behavior, with a degree of variability that, in essence, depends on the built urban environment. Therefore, it is concluded that the soundscape must be incorporated during urban planning processes, so that special attention is paid to the healthy balance between ecotopophony and anthropophony produced in the open public space of the city. Indeed, this is an area that can contribute to the shaping of sound experiences universally accepted by urban inhabitants. In short, it is recommended to expand the evaluation scale in future studies and to deepen the understanding of the city and its resulting soundscape.